I wouldn't use the weather stripping idea. As I did that on our 2006 mega can and found it leaking.
What I did recently was I removed the flooring and found a spot where I could drill through at an angle and add a grommet there to keep the moisture down and out. Haven't had any issues with it and since the wire lays flat no marks in the carpet. I seal around the outside just incase.
Last two trucks have done this and no issues.
2016 Ram 3500 4x4 Big Horn Crew Cab, SRW. Cummins Turbo Diesel Automatic 68RFE Trans
50 gallon diesel Transfer Flow tank with the Traxx 3 system.
2017 Sierra FLIK 5th Wheel
42' Front Livingroom, 15K
Hydraulic level up system