Miles,
I don't fish fresh water but Lake Okeechobee is legendary for bass fishing. Check out Roland Martin marina in Clewiston on the south rim. There likely are also guides etc on the north rim in the town of Okeechobee I've heard tales of strikes on every cast and 100 bass hooked up in a few hours. Go hunt some wild hogs while you're there.
Beyond lake O, there are plenty of streams, smaller lakes etc in the northern section of Fl. Check out Lake Seminole.
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