Actually, I-80 doesn't go to Denver but rather continues west to SLC where you can pick up I-15 south to St. George. This route through WY is a lower elevation crossing of the Continental Divide, but the winds across WY always seem to be blowing.
From I-80, you can catch I-76 to Denver and take I-70 through the mountains. Two serious climbs, but a beautiful route used by many RV's and trucks. From Vail pass west, there are a few short climbs, but nothing of significance. As noted above, there are alternate routes southward off of I-70 taking you through lots of fantastic scenery.
As far as big cities, SLC and Denver can be equally good or bad, depending on the day and time you travel through them. I do think that I-76 to where it connects with I-70 is generally a less busy route that I-70 itself through Denver.
We have found that I-80 in the Midwest/Great Lakes area has more truck traffic and is busier than I-70.
Ken & Allison
2 Camping Cats (1 diabetic)
1996 4Runner, TRD Supercharger, Edelbrock headers
2007 Fleetwood Arcadia, Honda EU2000i
4 mountain bikes, 1 canoe, 4 tents, 8 sleeping bags, 2 backpacks
(You get the idea!)