Do an internet search on Ford E450 fuse block diagram/daytime running lights. It might be a fuse that's required to actuate the DRL function. I wanted to be able to disable it on my 2002 Roadtrek (Chevy Express 3500 van), and it was easily disabled by pulling the correct fuse.
Mike. Comments are anecdotal or personal opinions, and worth what you paid for them.
2018 (2017 Sprinter Cab Chassis) Navion24V + 2016 Wrangler JKU (sold @ ????)
2016 Sunstar 26HE, V10, 3V, 6 Speed (sold @ 4600 miles)
2002 Roadtrek C190P (sold @ 315,000kms)