I agree with 2gypsies, taking Hwy 85 south to I-8 is a good route (we've done it several times).
lhenry, if your wife is ready to stop when reaching the I-8 , there is a KOA near there at 85/I-8, excellent, clean, remodeled KOA. The owner is Scott and is super nice and is working very hard to make that the best KOA in the system!
Once on the I-8, it runs right into I-10 and it's an easy drive.
Safe travels,
MM.
Mr.Mark
2021.5 Pleasure Way Plateau FL Class-B on the Sprinter Chassis
2018 Mini Cooper Hardtop Coupe, 2 dr., 6-speed manual
(SOLD) 2015 Prevost Liberty Coach, 45 ft, 500 hp Volvo
(SOLD) 2008 Monaco Dynasty, 42 ft, 425 hp Cummins