All you can do is tear out to the next "joist" and 'box' it in as best you can..
Gotta be able to get all the "cancer" out and still be able to keep the support all around.
You might be able to add your own additional support with additional cross "joists" to help keep the hole from getting too large...
Good luck!
Mitch
2013 F150 XLT 4x4 SuperCab Max Tow Egoboost 3.73 gears #7700 GVWR #1920 payload. 2019 Rockwood Mini Lite 2511S.