Will the MC work with the OP's TC? Most likely it will. It is a very capable truck. Will it need suspension upgrades? Perhaps. It seems that the OP is new and green to TC's (OP correct me if this assumption is wrong) and for her to expect that a DRW truck will solve all concerns right-out-of-the-box may not happen without soem upgrades.
Vinsil- appreciate you pointing out the specifics of that Palomino camper situation. The fact that it did happen on an odd camper should give pause to Mega cab owners to at least be aware of the occurrence to take that extra step to confirm there is not a conflict... especially when laying down the jack on a new truck. The new Mega's, especially on a short bed, have the taper of the fender wells back towards the bumper than compared to the original Mega cabs (or the current long bed Ford DRW long beds for example.) The flared DRW fenders as opposed to "tack-on" hip fenders are a new concern that TC owners will need to account for in terms of possible fitment comparability. Doubt it will be an issue, but certainly need to be educated about it.
The OP has gone through a lot of steps just to go camping... selling a low mileage awesome truck, buying a camper, buying a new truck... I would hate to have false expectations that a new truck will solve all issues without perhaps some upgrades let alone a major conflict.
To the OP... just pointing out others' experiences for you to be aware of. DYDD and keep us posted. We will want pictures of your set-up once you get it going.
Sold the TC, previous owner of 2 NorthStar pop-ups & 2 Northstar Arrows...still have the truck:
2005 Dodge 3500 SRW, Qcab long bed, NV-6500, diesel, 4WD, Helwig, 9000XL,
Nitto 285/70/17 Terra Grapplers, Honda eu3000Is, custom overload spring perch spacers.