Nashville can be a nightmare. Indianapolis can be a nightmare. Cincinnati can be a nightmare. Atlanta will usually be a nightmare. Louisville will be a nightmare until they finish the work replacing the bridge. That's just your route, from somewhere in the south to Michigan.
The problem is that the Interstate system, conceived by Eisenhower to connect military installations, turned into a commercial network connecting major cities, and providing expansion of urban expressway systems to allow those cities to spread into suburbs. So the system routes you from one point of congestion to another.
From Florida to Michigan, there is nothing better than I-75, though it routes you through 2-3 congestion points. From the central Gulf Coast to the Detroit area, you have to deal with Nashville, then either Louisville and Indianapolis or Knoxville and Cincinnati, if your preference is Interstate highways.
My experience is mostly Tulsa to Detroit, the choke points being St Louis or Kansas City, then Chicago or Indianapolis, depending on the route I choose. I've worked out at least a dozen other routes that use U.S. numbered highways and sometimes state highways to avoid all of those cities by 50 to 100 miles, but any of my non-Interstate alternatives adds 6 to 8 hours to 16-18 hour trip on the Interstates. So I'm not saving any time, just the hassle of urban freeway congestion and the possibility of 1-2 hours stuck in urban traffic.
I've not yet worked out an "avoid the cities" route for your trip, you haven't given me a from where to where, but I'm sure I could come up with a route that gets you off the Interstate system for much of your trip, and avoid Nashville. However, doing this might add 50-100% to your total travel time, taking you through a hundred towns where you creep through at 20-40 mph for 2-10 miles each.
With a few minutes working a trip planning program, you could probably work out alternatives that fit your needs and avoid choke points. You just have to decide whether an extra day or two of travel is a good tradeoff for avoiding urban freeway frustrations.
FWIW, when using the Interstate system, time of day for each city is important. Thus, for Detroit to Tulsa vs Tulsa to Detroit, my routes are completely different. Southbound catches Chicago and Kansas City at a good time of day. Northbound better fits the timing through St Louis.
Tom Test
Itasca Spirit 29B