Are you looking for scenery and side trips, or speed? If you're in no hurry, there are dozens of ways to go north and see the sights, staying off the interstates like 95 and 81. Two that I would use if I wanted to see the sights are US 301 or US 17. I'm sure there are others farther inland as well, but I'm not familiar with them, so I'll let others chime in.
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