Depending on your route south, if you are on the 101 I recommend the 126 east to the 5, then south a short distance on the 5 to the 210. Try to be through Pasadena before 2:30PM on weekdays. I used to commute there 50 miles each way. You will get slowing around Baldwin Ave. either direction no matter what time of day due to the mall traffic.
Just before Pasadena there is always slowing at the tunnel where the 210 and 134 merge. Also some slowing at the 210 & 605, and the 210 & 57, but after that you can get on the 15 and go fairly well.
In the HOV lane at about Madre there is a killer hole in that lane for a drainage gate. Don't you dare hit it; stay to the right edge at that area.
I don't recommend the 118 unless the 126 is jammed. If so, exit the 126 in the middle of Fillmore and go south on the 23 until the 118. You would have to use the 23 to get to Moorpark in order to get on the 118 West to the 210.
MOTHER SHIP Winnebago View 24H (2007 Dodge Sprinter 3500 Chassis, 2008 Body)3.0 L M-B Diesel V6 bought used with 24K miles. Toad: ROCKY the Flying Squirrel.