Does your Ignition Coil look like
Or like
???
The second coil, cylindrical "can" would overheat and stop the vehicle (at least it did that to me) then run when it cooled.
I don't know if the coil pictured first (which is not an oil-filled cylinder and IS the one I looked up for 1989 E350/460/EFI) tends to do the same trick.
We nearly canceled a trip, towing a car 200 miles in FL summer heat with A/C on. After it cooled, we ran the last 50 miles running the car separately and A/C off in the RV, with no problem. I replaced the coil before we ran back, and the problem never repeated.
If God's Your Co-Pilot Move Over, jd
2003 Jayco Escapade 31A on 2002 Ford E450 V10 4R100 218" WB