We have a similar size coach except on a E350 vs 450 but our weights are not going to be that much different. We tend to run on full water and fuel as well as more junk than we need. I concur with the comments above. Personally, I run 60 front, 70 rear and check the pressure every day in the morning before traveling. I also carry an infrared thermometer and check tire temperature during the day when we make a rest stop. That lets me know if one of the tires is building up excessive internal heat. We Cant Wait in the post above is on target in my experience. You can sometimes greatly improve the ride with a little less air. More is not necessarily good in this case.
Also, you might think about changing your tire pressure if making a long trip on a very hot day. In the Southwest we often run several hundred miles down an interstate when it is 100F ambient and that pavement will cook an egg....and add more than you might think to your tire pressure.
Seems every rig is a little different and everyone's concept of an acceptable ride is also different. I think you will find a lot of discussion on this topic if you use the search function on this forum.
Paul
PSW
2013 Phoenix Cruiser 2350
2014 Jeep Cherokee behind it
and a 2007 Roadtrek 210P for touring