Experienced this first hand...bought a used 2000 Honda Odyssey with about 130,000 miles on it.
Had advised anyone who would ask/listen to flush their automatic.
Generally no problems...but...there is a chance to loosen or dissolve deposits (varnish is the main thing) on precision mating/sliding/etc parts. That will either float to make something stick and/or the mating/sliding parts no longer have the precision needed to do their jobs
On a trip to visit grandson in S Calif and loaded with tools to help SIL remodel their garage...coming back running down "The Grape Vine"...noticed the tranny shifting 'funny'. Lethargic both up-shifting and downshifting on the grades. After getting home...it continued to shift weird. Had the tranny's ATF flushed before the trip and all seemed fine for the weeks before that trip.
Mechanic said Odyssey's automatic is the weak system and he rebuilds tons of them. Mostly folks who load up to GVWR and/or tows. $3K cost and now know the automatic is the weak link from experience...
He says they tend to over heat the ATF and he has to clean the varnishes, but replaces valve bodies as that is where the main issue resides.
Now have an in-line ATF filter and he says to put in an after market ATF cooler...but there isn't enough room for that. At 18 years old...am considering getting another used Odyssey and think sooner than want to...
Suggest the OP just do the pan, filter and leave the majority of the old ATF in there....as long as it isn't too dark...nor smells of burnt ATF...do the white tissue test...
On high mileage trannies & ATF...it is 50/50 chance of creating a problem...or better stated...unmasking a potential failure now rather than it doing so by itself...
-Ben
Picture of my rig1996 GMC SLT Suburban 3/4 ton K3500/7.4L/4:1/+150Kmiles orig owner...
1980 Chevy Silverado C10/long bed/"BUILT" 5.7L/3:73/1 ton helper springs/+329Kmiles, bought it from dad...
1998 Mazda B2500 (1/2 ton) pickup, 2nd owner...
Praise Dyno Brake equiped and all have "nose bleed" braking!
Previous trucks/offroaders: 40's Jeep restored in mid 60's / 69 DuneBuggy (approx +1K lb: VW pan/200hpCorvair: eng, cam, dual carb'w velocity stacks'n 18" runners, 4spd transaxle) made myself from ground up / 1970 Toyota FJ40 / 1973 K5 Blazer (2dr Tahoe, 1 ton axles front/rear, +255K miles when sold it)...
Sold the boat (looking for another): Trophy with twin 150's...
51 cylinders in household, what's yours?...