I have a 2015 F250 with the same engine. I have had a couple of DEF Filter issues. Once halfway between Roswell and Albuquerque (had to be towed). Next time was on HW50 in the middle of NV. Luckily that time I managed to get it to "self-clean" by dropping down a couple of gears and driving it for a hour at 3000 RPMs. Ford never has come up with a good explanation for either issue.
Oh, also had the transfer case go out. Was in the shop for a month.
Now have a check engine light on for a sensor of some sort.
All in the first 30000 miles.
2015 Jayco 27RLS
2015 F250 PSD