I have carried two Bigfoot campers in my F350 (not at the same time!). I had a plastic liner in for the first one (9.6) with a 2" platform on top. It didn't move much. The 10.4 Bigfoot seemed to move more, and on the advice of people on this forum I removed the plastic liner and put in Line-X. The camper moves just as much with Line-X as it did on the plastic liner. The camper sat on a rubber pad in both cases. I had it move quite a lot on one particular trip, heavy crosswind bumpy two lane with semis blowing by the other direction. I ended up making a 3/4" plywood platform that fit the bed of the truck pretty close so it wouldn't move, and putting low rails on it to keep the camper in place. This has been completely successful.
Conclusion: 1) there was no difference in camper shifting between the poly bed liner and the Line-X.
2) A rubber pad might help, but will not always solve the problem.
3) Line-X is nice paint, but is expensive does not protect the bed like a poly liner will.
4) Especially since you need the 2" platform anyway, just add to it so that it is corralled by the bed and won't move, and put low rails on it (2" high is plenty, these are 1.5") so that the camper cannot move on it.
This is all you need:
As an aside: if you put a poly liner in a pickup, you need a liner liner. This is 1/8 inch polyethylene foam sheet, under the poly liner (accessory stores sell it, or you can just buy the material). It keeps the dust and grit from destroying the paint on the bed. My poly liner was installed by the dealer when I picked up my new truck. I took it home and immediately installed the liner liner under it. When I removed the poly liner at 13 years old and 83,000 miles, the bed looked like it had just come from the showroom. There were only two or three very small places (far less than 1 sq in total area) where the liner liner was rubbed through and the paint was worn to shiny metal. Everywhere else the paint was perfect. This is the 3rd truck I have done this to with the same result (first one I owned had no liner liner and the liner ate the paint). At this point I regret paying for the Line-X- cost money, does not protect the bed very well, and solved no problem.
Bigfoot 10.4E, 2015 F350 6.7L DRW 2WD, Autoflex Ultra Air Ride rear suspension, Hellwig Bigwig sway bars front and rear